![]() ![]() Original magnification, 63× scale bar, 20 μm. A, Representative images of IF staining of NETs in patients with early- or advanced-stage DLBCL. Levels of NETs are higher in advanced-stage DLBCL and correlate with inferior survival. J, NETs in tumor tissues were positively correlated with serum MPO–DNA level, n = 60, r = 0.7754, P < 0.001, Pearson correlation. ![]() Log-rank test and univariate Cox regression analysis. I, Patients with higher MPO–DNA ( n = 24) had worse PFS than lower MPO–DNA group ( n = 62). H, Plasma MPO–DNA levels were significantly higher in advanced-stage patients. F and G, In the validation set, higher NETs group ( n = 34) had poorer PFS and OS than lower NETs group ( n = 65). P value and HR were calculated by log-rank test and univariate Cox regression analysis, respectively. D and E, In the training cohort, PFS and OS were significantly better in the lower NETs group ( n = 79) than in the higher NETs group ( n = 44). Advanced versus early: 3.5 (0–20) versus 1 (0–7) P = 0.000, Mann–Whitney U test. C, In the validation set, advanced-stage patients presented with more NETs. Mann–Whitney U test, early stage, median = 2 NETs/field, range, 0–6 advanced-stage, median = 3 NETs/field, range, 0–15 P = 0.035. B, In the training cohort, more NETs are presented in advanced-stage DLBCL tissues. ![]()
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